Zaldiar is a prescription pain-relief medication that combines tramadol hydrochloride 37.5 mg and paracetamol 325 mg in each tablet. It’s used to treat moderate to severe pain when other analgesics alone are not sufficient.
Mechanism of Action
- Tramadol works by binding to opioid receptors and affecting serotonin and norepinephrine reuptake, which helps reduce the perception of pain.
- Paracetamol (acetaminophen) acts as a central analgesic and antipyretic, lowering fever and relieving pain.
- Together, these components create a synergistic effect, providing stronger pain relief than either drug alone.
Indications
Zaldiar is indicated for:
- Moderate to severe acute pain
- Pain after surgery or injury
- Cases where paracetamol or NSAIDs alone are insufficient
Dosage & Administration
- Adults and adolescents over 14 years: the usual starting dose is 2 tablets.
- Repeat doses may be taken every 6 hours as needed.
- Maximum dose: 8 tablets per day.
- Treatment duration should be kept as short as possible and always under medical supervision.
Warnings & Precautions
- Not suitable for children under 14 years.
- Do not exceed the maximum daily dose.
- Use with caution in patients with kidney or liver impairment.
- May cause drowsiness and dizziness — avoid driving if affected.
- Should not be taken with alcohol or other sedatives.
Possible Side Effects
- Common: nausea, vomiting, constipation, dizziness, drowsiness, headache
- Less common: sweating, mood swings, confusion, insomnia
- Severe side effects are rare but require immediate medical attention
Where to Buy in Israel
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