Wegovy is a prescription medication containing Semaglutide, a GLP-1 receptor agonist used for chronic weight management. It is indicated for adults with obesity (BMI ≥30) or overweight (BMI ≥27) with at least one weight-related condition, such as type 2 diabetes, hypertension, or high cholesterol.
Mechanism of Action
- Semaglutide mimics the action of the natural hormone GLP-1, which regulates appetite and food intake.
- It works by:
- Increasing feelings of fullness (satiety)
- Slowing gastric emptying
- Reducing appetite
- Enhancing insulin secretion in response to meals
- Suppressing glucagon release, which helps lower blood sugar levels
Dosing Schedule
Wegovy is administered as a subcutaneous injection once weekly. The dosing schedule involves a gradual increase to minimize gastrointestinal side effects:
- Month 1: 0.25 mg weekly
- Month 2: 0.5 mg weekly
- Month 3: 1.0 mg weekly
- Month 4: 1.7 mg weekly
- Month 5 and onward: 2.4 mg weekly (maintenance dose)
Note: The maximum recommended dose is 2.4 mg weekly.
Instructions for Use
- Administration:
- Inject once weekly on the same day each week, at any time of day, with or without meals.
- Rotate injection sites between the abdomen, thigh, or upper arm.
- Do not inject into the same site consecutively.
- Missed Dose:
- If a dose is missed, administer it as soon as possible within 5 days.
- If more than 5 days have passed, skip the missed dose and resume the regular dosing schedule.
- Storage:
- Store in the refrigerator (2°C to 8°C).
- Do not freeze.
- After the first use, Wegovy can be stored at room temperature for up to 28 days.
Side Effects
Common side effects may include:
- Nausea
- Vomiting
- Diarrhea
- Constipation
- Abdominal pain
- Decreased appetite
Note: These side effects often decrease over time as the body adjusts to the medication.
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