Trazodil (Trazodone) 50 mg / 100 mg is an antidepressant medication used to treat depression, anxiety disorders and insomnia associated with mood disturbance. It helps improve mood, reduce anxiety, and support sleep quality in patients suffering from depressive or anxious states.
Mechanism of Action
- Trazodone works by increasing serotonin levels in the brain via inhibition of serotonin reuptake.
- It also blocks certain serotonin receptors (5-HT₂), which contributes to its sedative and anxiolytic effects.
- At lower doses (50 mg), the sleep-promoting effects are more pronounced, while higher doses (100 mg and above) are used for depression and anxiety.
Indications
Trazodil is prescribed for:
- Major depressive disorder
- Generalized anxiety disorder and panic disorder
- Insomnia linked with depression or anxiety
- Sometimes adjunctively in treatment of chronic pain with mood component
Dosage & Administration
- Starting dose for adults usually 50-100 mg once daily, often at bedtime if insomnia is primary concern.
- For depression/anxiety, dosage may be divided throughout the day.
- Maintenance dose can be increased based on clinical response and tolerability.
- Maximum dose outpatient: typically up to 400 mg/day; in special settings may be higher under supervision.
Warnings & Precautions
- Avoid use in pregnancy or lactation without medical advice.
- Caution in patients with liver or kidney impairment.
- Possible side effects: drowsiness, dizziness, dry mouth, headache, blurred vision.
- Combining with alcohol or other central nervous system depressants increases risk of sedation.
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