Sayana 104mg (Medroxyprogesterone): Modern Subcutaneous Long-Acting Contraception in Israel

Reliable and convenient contraception is a cornerstone of women’s health and personal freedom. The daily burden of oral contraceptive pills often brings inconvenience and the risk of missed doses, which can significantly compromise contraceptive reliability.

The modern standard for long-acting progestin-only hormonal contraception is Sayana 104mg.

The active pharmaceutical ingredient is Medroxyprogesterone Acetate (104mg / 0.65ml). It is presented as a pre-filled syringe containing a suspension for subcutaneous injection. A single administration provides highly effective contraceptive protection for 3 months (12 weeks) by inhibiting ovulation, thickening cervical mucus, and altering the endometrial lining.

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How Does Sayana 104mg Work?

Sayana delivers comprehensive, progestin-based contraceptive protection:

Ovulation Suppression: Prevents egg maturation and release from the ovaries throughout the entire 12-week period.
Cervical Mucus Thickening: Creates a natural physical barrier in the cervix that inhibits sperm penetration.
Endometrial Modification: Alters the uterine lining to prevent potential implantation.
Convenient Dosing: A single subcutaneous injection every 3 months eliminates the need for a daily pill routine.

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Sayana is widely preferred because of its comfortable subcutaneous delivery system (in contrast to intramuscular Depo-Provera), resulting in a gentler and less painful injection experience.

Indications for Use

Sayana 104mg is indicated for:

Long-term female contraception (especially suitable for women who find daily oral pill regimens difficult to maintain);
Contraception for women who have contraindications to estrogens;
Symptomatic management of endometriosis (under specialist gynecological guidance).

Key Advantages of Sayana 104mg

Exceptional Reliability: Pearl index approaches zero when injection schedules are strictly maintained.
Estrogen-Free Safety: Ideal for women with contraindications to estrogen-containing birth control (e.g., thromboembolism risks or breastfeeding mothers starting 6 weeks postpartum).
Subcutaneous Administration: Administered via a fine needle into the anterior thigh or abdomen.
Sustained Protection: Provides 12 weeks of continuous contraceptive coverage per injection.

Guidelines for Administration

Intended strictly for subcutaneous (SC) injection.
The initial injection should be administered within the first 5 days of a normal menstrual cycle.
Subsequent injections must be administered every 12 weeks (with a allowable window of +/- 1 week).
Always shake the pre-filled syringe vigorously before administration to ensure a uniform suspension.

Where to Buy Sayana 104mg in Israel?

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Explore related catalog sections:

Gynecology & Women’s Health → Hormonal Contraceptives

Technical Specifications

Product Name: Sayana 104mg
Active Ingredient: Medroxyprogesterone Acetate
Dosage Strength: 104mg / 0.65ml
Form: Subcutaneous injectable suspension in pre-filled syringe
Drug Class: Progestogen / Systemic hormonal contraceptive

Frequently Asked Questions (FAQ)

How does Sayana differ from Depo-Provera?

While both contain medroxyprogesterone, Sayana uses a lower dose (104mg vs. 150mg) and is injected subcutaneously rather than intramuscularly, allowing for smoother hormone release and less discomfort during injection.

How long does it take for fertility to return after stopping Sayana?

Return of ovulation and fertility occurs gradually, averaging between 4 to 12 months after the protective duration of the last injection expires.

Can Sayana be used while breastfeeding?

Yes. Because Sayana contains no estrogen, it does not adversely affect milk production and can be initiated 6 weeks postpartum following medical consultation.